Publications
Antibiotic treatment modestly reduces protection against Mycobacterium tuberculosis reinfection in macaques
Drug Treatment, Mechanisms of Protection
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Sharie Keanne Ganchua, Pauline Maiello, Michael Chao, Forrest Hopkins, Douaa Mugahid, Philana Ling Lin, Sarah M Fortune, JoAnne L Flynn
April 9, 2024
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Infection and Immunity
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
T cell Dynamics in TB
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Caylin G Winchell, Sarah K Nyquist, Michael C Chao, Pauline Maiello, Amy J Myers, Forrest Hopkins, Michael Chase, Hannah P Gideon, Kush V Patel, Joshua D Bromley, Andrew W Simonson, Roisin Floyd-O’Sullivan, Marc Wadsworth, Jacob M Rosenberg, Rockib Uddin, Travis Hughes, Ryan J Kelly, Josephine Griffo, Jaime Tomko, Edwin Klein, Bonnie Berger, Charles A Scanga, Joshua Mattila, Sarah M Fortune, Alex K Shalek, Philana Ling Lin, JoAnne L Flynn
October 16, 2023
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Journal of Experimental Medicine
Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
SIV Co-infection, TB vaccines
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Erica C Larson, Amy L Ellis-Connell, Mark A Rodgers, Abigail K Gubernat, Janelle L Gleim, Ryan V Moriarty, Alexis J Balgeman, Cassaundra L Ameel, Solomon Jauro, Jaime A Tomko, Kara B Kracinovsky, Pauline Maiello, H Jake Borish, Alexander G White, Edwin Klein, Allison N Bucsan, Patricia A Darrah, Robert A Seder, Mario Roederer, Philana Ling Lin, JoAnne L Flynn, Shelby L O’Connor, Charles A Scanga
October 9, 2023
Published on
Nature Microbiology
Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas
Mechanisms of Protection, T cell Dynamics in TB
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Nicole L Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O'Connor, Philana Ling Lin, Charles A Scanga, JoAnne L Flynn
April 11, 2023
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mBio
Characterizing the Spectrum of Latent Mycobacterium tuberculosis in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution
NHP model of Mtb infection
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Jessica Marie Medrano, Pauline Maiello, Tara Rutledge, Jaime Tomko, Mark A Rodgers, Daniel Fillmore, L James Frye, Christopher Janssen, Edwin Klein, JoAnne L Flynn, Philana Ling Lin
February 14, 2023
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Journal of Infectious Diseases
Multivariate Analysis Establishes Airway T Cells as a Correlate of IV BCG-Mediated Protection Against Tuberculosis in Rhesus Macaques
Mechanisms of Protection, T cell Dynamics in TB
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Darrah PA*, Zeppa JJ*, Wang C*, Irvine EB, Bucsan AN, Rodgers MA, Pokkali S, Hackney JA, Kamath M, White AG, Borish HJ, Frye LJ, Tomko J, Kracinovsky K, Lin PL, Klein E, Scanga CA, Alter G, Fortune SM, Lauffenburger DA, Flynn JL, Seder RA, Maiello P, Roederer M.
November 14, 2022
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Cell Host & Microbe
Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates
Myeloid Dynamics in TB
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Priyanka Talukdar, Beth F Junecko, Daniel S Lane, Pauline Maiello, Joshua T Mattila
September 13, 2022
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Frontiers in Immunology
Characterization of natural killer cells in the blood and airways of cynomolgus macaques during Mycobacterium tuberculosis infection
T cell Dynamics in TB
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Collin R. Diedrich, Tara Rutledge, Tonilynn M. Baranowski, Pauline Maiello, Philana Ling Lin
September 3, 2022
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Journal of Medical Primatology
T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques
T cell Dynamics in TB
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Nicole L Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H Jacob Borish, Jaime Tomko, L James Frye, Alexander G White, Denise E Kirschner, Joshua T Mattila, JoAnne L Flynn
May 17, 2022
Published on
Cell Reports
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Mechanisms of Protection
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Hannah P Gideon, Travis K Hughes, Constantine N Tzouanas, Marc H Wadsworth II, Ang Andy Tu, Todd M Gierahn, Joshua M Peters, Forrest F Hopkins, Jun-Rong Wei, Conner Kummerlowe, Nicole L Grant, Kievershen Nargan, Jia Yao Phuah, H Jacob Borish, Pauline Maiello, Alexander G White, Caylin G Winchell, Sarah K Nyquist, Sharie Keanne C Ganchua, Amy Myers, Kush V Patel, Cassaundra L Ameel, Catherine T Cochran, Samira Ibrahim, Jaime A Tomko, Lonnie James Frye, Jacob M Rosenberg, Angela Shih, Michael Chao, Edwin Klein, Charles A Scanga, Jose Ordovas-Montanes, Bonnie Berger, Joshua T Mattila, Rajhmun Madansein, J Christopher Love, Philana Ling Lin, Alasdair Leslie, Samuel M Behar, Bryan Bryson, JoAnne L Flynn, Sarah M Fortune, Alex K Shalek
May 10, 2022
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Immunity
Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis
SIV Co-infection
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Ryan V Moriarty, Mark A Rodgers, Amy L Ellis, Alexis J Balgeman, Erica C Larson, Forrest Hopkins, Michael R Chase, Pauline Maiello, Sarah M Fortune, Charles A Scanga, Shelby L O'Connor
April 25, 2022
Published on
Microbiology Spectrum