Publications
Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis
Mucosal Immunology
Davide Pisu, Persis S Sunny, Molly L Nelson, Beth F Junecko, Roopa Venugopalan, Mark A Rodgers, H Jacob Borish, Pauline Maiello, Charles A Scanga, Philana Ling Lin, JoAnne L Flynn, David G Russell, Joshua T Mattila
February 4, 2026
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Myeloid Dynamics in TB
Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages
Mucosal Immunology
Andrew W Simonson, Michael C Chao, Luke E Hood, Rachel A Donlan, Forrest Hopkins, Michael R Chase, Andrew J Vickers, Alanna Callendrello, Edwin Klein, HJacob Borish, Marshall Malin, Pauline Maiello, Charles A Scanga, Philana Ling Lin, Sarah M Fortune, JoAnne L Flynn
November 2, 2025
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Mechanisms of Protection, NHP model of Mtb Infection, TB Disease
Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model
Infection and Immunity
Pauline Maiello*, Collin Diedrich*, Tara Rutledge, Mark Rodgers, Kara Kracinovsky, H Jacob Borish, Alexander White, Forrest Hopkins, Michael C Chao, Edwin Klein, Sarah Fortune, JoAnne L Flynn, Philana Ling Lin
June 23, 2025
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Imaging, NHP model of Mtb Infection, TB Disease
Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes
Journal of Experimental Medicine
Andrew W Simonson*, Joseph J Zeppa*, Allison N Bucsan*, Michael C Chao, Supriya Pokkali, Forrest Hopkins, Michael R Chase, Andrew J Vickers, Matthew S Sutton, Caylin G Winchell, Amy J Myers, Cassaundra L Ameel, Ryan J Kelly, Ben Krouse, Luke E Hood, Jiaxiang Li, Chelsea C Lehman, Megha Kamath, Jaime Tomko, Mark A Rodgers, Rachel Donlan, Harris Chishti, H Jacob Borish, Edwin Klein, Charles A Scanga, Sarah M Fortune, Philana Ling Lin, Pauline Maiello, Mario Roederer, Patricia A Darrah, Robert A Seder, JoAnne L Flynn
February 6, 2025
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Mechanisms of Protection, T cell Dynamics in TB, TB Vaccines
A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity
Nature Microbiology
Alexander A Smith*, Hongwei Su*, Joshua Wallach*, Yao Liu, Pauline Maiello, H Jacob Borish, Caylin Winchell, Andrew W Simonson, Philana Ling Lin, Mark Rodgers, Daniel Fillmore, Jennifer Sakal, Kan Lin, Valerie Vinette, Dirk Schnappinger, Sabine Ehrt, JoAnne L Flynn
January 10, 2025
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Mechanisms of Protection, TB Vaccines
Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques
Cell Systems
Shu Wang*, Amy J Myers*, Edward B Irvine, Chuangqi Wang, Pauline Maiello, Mark A Rodgers, Jaime Tomko, Kara Kracinovsky, H Jacob Borish, Michael C Chao, Douaa Mugahid, Patricia A Darrah, Robert A Seder, Mario Roederer, Charles A Scanga, Philana Ling Lin, Galit Alter, Sarah M Fortune, JoAnne L Flynn, Douglas A Lauffenburger
December 18, 2024
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Mechanisms of Protection, TB Vaccines
Transiently boosting Vγ9+ Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance
Infection and Immunity
Erica C Larson, Amy L Ellis, Mark A Rodgers, Abigail K Gubernat, Janelle L Gleim, Ryan V Moriarty, Alexis J Balgeman, Yonne T de Menezes, Cassaundra L Ameel, Daniel J Fillmore, Skyler M Pergalske, Jennifer A Juno, Pauline Maiello, Harris B Chishti, Philana Ling Lin, Dale I Godfrey, Stephen J Kent, Daniel G Pellicci, Lishomwa C Ndhlovu, Shelby L O'Connor, Charles A Scanga
December 10, 2024
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Mechanisms of Protection, SIV Co-infection, T cell Dynamics in TB
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
Immunity
Joshua D Bromley*, Sharie Keanne C Ganchua*, Sarah K Nyquist, Pauline Maiello, Michael Chao, H Jacob Borish, Mark Rodgers, Jaime Tomko, Kara Kracinovsky, Douaa Mugahid, Son Nguyen, Qianchang Dennis Wang, Jacob M Rosenberg, Edwin C Klein, Hannah P Gideon, Roisin Floyd-O’Sullivan, Bonnie Berger, Charles A Scanga, Philana Ling Lin, Sarah M Fortune, Alex K Shalek, JoAnne L Flynn
October 8, 2024
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Mechanisms of Protection, T cell Dynamics in TB
Antibiotic treatment modestly reduces protection against Mycobacterium tuberculosis reinfection in macaques
Infection and Immunity
Sharie Keanne Ganchua, Pauline Maiello, Michael Chao, Forrest Hopkins, Douaa Mugahid, Philana Ling Lin, Sarah M Fortune, JoAnne L Flynn
April 9, 2024
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Drug Treatment, Mechanisms of Protection
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
Journal of Experimental Medicine
Caylin G Winchell, Sarah K Nyquist, Michael C Chao, Pauline Maiello, Amy J Myers, Forrest Hopkins, Michael Chase, Hannah P Gideon, Kush V Patel, Joshua D Bromley, Andrew W Simonson, Roisin Floyd-O’Sullivan, Marc Wadsworth, Jacob M Rosenberg, Rockib Uddin, Travis Hughes, Ryan J Kelly, Josephine Griffo, Jaime Tomko, Edwin Klein, Bonnie Berger, Charles A Scanga, Joshua Mattila, Sarah M Fortune, Alex K Shalek, Philana Ling Lin, JoAnne L Flynn
October 16, 2023
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T cell Dynamics in TB