JoAnne Flynn, PhD
Distinguished Professor & Chair, Microbiology & Molecular Genetics
The Flynn lab focuses on tuberculosis. We study host-pathogen interactions, immunology of tuberculosis, vaccines and drugs. We developed and use non-human primate models of tuberculosis for all our work. We also study HIV/M. tuberculosis co-infections in non-human primate models.
Chuck Scanga, PhD
Research Associate Professor, Microbiology & Molecular Genetics
The Scanga lab utilizes imaging techniques such as PET/CT to follow in vivo the response to antibiotic regimens, vaccines and SIV/HIV co-infection on M. tuberculosis infection in non-human primates. We analyze immune responses and disease progression with the ultimate goal to help design more effective vaccines and chemotherapeutic regimens.
Philana Ling Lin, MD, MSc
Associate Professor, Pediatrics
Our lab is focused on the host protective immune responses to M. tuberculosis, a major factor in outcome of infection. We are able to simulate both M. tuberculosis infection and SIV-Mtb co-infection in animal models and follow disease progression using in vivo PET-CT imaging. Our current studies involve identifying immunologic causes and bacterial sources of reactivation TB and relapse after treatment.
Josh Mattila, PhD
Assistant Professor, Infectious Disease & Microbiology
The Mattila Lab is working to understand interactions between M. tuberculosis and the host at the granuloma level especially with regard to macrophage and neutrophil responses against M. tuberculosis that can be disrupted by HIV infection. We pair ex vivo, in vitro and in silico approaches to evaluate changes in immunometabolism, signaling, and cellular infiltration during granuloma formation.
Patty Grace, PhD
Assistant Professor, Microbiology & Molecular Genetics
The Grace lab is identifying humoral correlates and mechanisms that lead to favorable outcomes in Mtb infection. By using human and mouse models, we are able to investigate the interaction of antibodies with TB antigens
and antibody-FcR mechanisms of bacterial restriction.
Andrew Simonson, PhD
Research Assistant Professor, Microbiology & Molecular Genetics
The Simonson Lab is working to understand early host interactions during M. tuberculosis infection using in vivo and ex vivo models. We are particularly interested in characterizing rapidly responding lymphocyte populations that can influence the success or failure of lesion containment.